He is the former undisputed BAMMA Featherweight Champion and undisputed BAMMA Bantamweight Champion, and fought in the bantamweight division of the Ultimate Fighting Championship (UFC).

He is known for his quick striking and dynamic style. In 2015, Duquesnoy was named the #1 featherweight prospect in the world and "one of the very best talents in all of MMA", and was ranked the #1 prospect worldwide in all of MMA for both 2016 and 2017.